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What to Watch in the Week Ahead and on Monday, November 4

What to Watch in the Week Ahead and on Monday, November 4 The Day Ahead is an email and PDF publication that includes the day's major stories and events, analyses and other features. To receive The Day Ahead, Eikon users can register at DAY/US . Thomson One users can register at RT/DAY/US. All times in ET/GMT ON MONDAY On the U.S. economic front, the Commerce Department's Census Bureau is set to show that factory orders likely dropped 0.4% in September after falling 0.2% in August.
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U.S. Agilon Health, Alphabet, Crocs

U.S. RESEARCH ROUNDUP-Agilon Health, Alphabet, Crocs Oct 30 (Reuters) - Wall Street securities analysts revised their ratings and price targets on several U.S.-listed companies, including Agilon Health, Alphabet and Crocs, on Wednesday. HIGHLIGHTS * Agilon Health Inc AGL.N : Citigroup cuts to sell from neutral * Alphabet Inc GOOGL.O : Seaport Research Partners raises to buy from neutral * Crocs Inc CROX.O : Raymond James cuts to market perform from outperform * Leggett & Platt Inc LEG.N : Piper
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Biotech M&A to show less 'fire power' in 2024 due to low-valued deals

LIVE MARKETS-Biotech M&A to show less 'fire power' in 2024 due to low-valued deals Main U.S. indexes red; Dow off most, down ~0.8% Real Estate weakest S&P sector; Tech sole gainer Dollar up; crude gains ~2%; gold ~flat; bitcoin down ~2.5% U.S. 10-Year Treasury yield jumps to ~4.18% Welcome to the home for real-time coverage of markets brought to you by Reuters reporters.
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Nasdaq top and bottom performing stocks at about 03:45 p.m. EDT

BUZZ - Nasdaq top and bottom performing stocks at about 03:45 p.m. EDT Nasdaq 100 .NDX Top Performers Percent Change Broadcom Inc AVGO.OQ +2.9% Micron Technology Inc MU.OQ +2.8% ASML Holding NV ASML.OQ +2.6% Vertex Pharmaceuticals Inc VRTX.OQ +2.1% Arm Holdings PLC ARM.OQ +1.8% Bottom Performers Percent Change CSX Corp CSX.OQ -6.4% Moderna Inc MRNA.OQ -4.0% Warner Bros Discovery Inc WBD.OQ -3.6% PDD Holdings Inc PDD.OQ -3.2% Lululemon Athletica Inc LULU.OQ -3.2% The Nasdaq 100 .NDX gained 38.10
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Why gene therapy for sickle cell is slow to catch on with patients

INSIGHT-Why gene therapy for sickle cell is slow to catch on with patients By Deena Beasley LOS ANGELES, Sept 28 (Reuters) - Student Zoe Davis, 20, was just weeks into her junior year when she landed back in the hospital with severe sickle cell pain earlier this month. She is doing what she can to prevent the crippling attacks in her arms, legs and abdomen that are becoming more frequent.
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Pfizer's Oxbryta exit may hasten trials of rival experimental sickle cell drugs, analysts say

UPDATE 1-Pfizer's Oxbryta exit may hasten trials of rival experimental sickle cell drugs, analysts say EMA raises concerns about deaths in Oxbryta trials Shares of Agios and Fulcrum rise after Pfizer's decision Adds FDA statement in paragraph 4 By Kashish Tandon and Christy Santhosh Sept 26 (Reuters) - Pfizer's PFE.N decision late on Wednesday to withdraw its sickle cell disease treatment due to the risk of death could help speed up trials of new experimental rivals, Wall Street analysts said.
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Pfizer's Oxbryta exit may hasten trials of rival experimental sickle cell drugs, analysts say

Pfizer's Oxbryta exit may hasten trials of rival experimental sickle cell drugs, analysts say EMA raises concerns about deaths in Oxbryta trials Shares of Agios and Fulcrum rise after Pfizer's decision By Kashish Tandon and Christy Santhosh Sept 26 (Reuters) - Pfizer's PFE.N decision late on Wednesday to withdraw its sickle cell disease treatment due to the risk of death could help speed up trials of new experimental rivals, Wall Street analysts said.
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Health Canada Grants Marketing Authorization Of First Crispr/Cas9 Gene-Edited Therapy, Casgevy® (Exagamglogene Autotemcel), For The Treatment Of Sickle Cell Disease And Transfusion-Dependent Beta Thalassemia

BRIEF-Health Canada Grants Marketing Authorization Of First Crispr/Cas9 Gene-Edited Therapy, Casgevy® (Exagamglogene Autotemcel), For The Treatment Of Sickle Cell Disease And Transfusion-Dependent Beta Thalassemia Vertex Pharmaceuticals Inc VRTX.O : HEALTH CANADA GRANTS MARKETING AUTHORIZATION OF FIRST CRISPR/CAS9 GENE-EDITED THERAPY, CASGEVY® (E
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Bluebird bio to cut 25% of jobs in fresh bid to battle cash crunch

UPDATE 2-Bluebird bio to cut 25% of jobs in fresh bid to battle cash crunch Adds CEO statement in paragraph 5, background throughout Sept 24 (Reuters) - Bluebird bio BLUE.O will lay off about 25% of its workforce, or 95 employees, the gene therapy maker said on Tuesday, in a second major restructuring in two years as the company focuses on launching its treatments amid a cash crunch.
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Nasdaq top and bottom performing stocks at about 03:45 p.m. EDT

BUZZ - Nasdaq top and bottom performing stocks at about 03:45 p.m. EDT Nasdaq 100 .NDX Top Performers Percent Change Dollar Tree Inc DLTR.OQ +7.2% Tesla Inc TSLA.OQ +4.3% Zscaler Inc ZS.OQ +3.1% Comcast Corp CMCSA.OQ +2.7% Amazon.com Inc AMZN.OQ +2.3% Bottom Performers Percent Change Copart Inc CPRT.OQ -6.6% Old Dominion Freight Line Inc ODFL.OQ -5.4% AstraZeneca PLC AZN.OQ -3.4% Super Micro Computer Inc SMCI.OQ -3.1% Vertex Pharmaceuticals Inc VRTX.OQ -2.6% The Nasdaq 100 .NDX lost 36.77 points
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Nasdaq top and bottom performing stocks at about 12:01 p.m. EDT

BUZZ - Nasdaq top and bottom performing stocks at about 12:01 p.m. EDT Nasdaq 100 .NDX Top Performers Percent Change Tesla Inc TSLA.OQ +3.2% Dollar Tree Inc DLTR.OQ +2.3% Amazon.com Inc AMZN.OQ +2.1% Comcast Corp CMCSA.OQ +1.6% Arm Holdings PLC ARM.OQ +1.2% Bottom Performers Percent Change Copart Inc CPRT.OQ -7.1% Old Dominion Freight Line Inc ODFL.OQ -6.8% AstraZeneca PLC AZN.OQ -3.5% Vertex Pharmaceuticals Inc VRTX.OQ -3.1% Regeneron Pharmaceuticals Inc REGN.OQ -3.0% The Nasdaq 100 .NDX lost 9
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Nasdaq top and bottom performing stocks at about 12:01 p.m. EDT

BUZZ - Nasdaq top and bottom performing stocks at about 12:01 p.m. EDT Nasdaq 100 .NDX Top Performers Percent Change Gilead Sciences Inc GILD.OQ +2.0% Vertex Pharmaceuticals Inc VRTX.OQ +1.8% Copart Inc CPRT.OQ +1.2% Verisk Analytics Inc VRSK.OQ +1.2% Old Dominion Freight Line Inc ODFL.OQ +1.1% Bottom Performers Percent Change Super Micro Computer Inc SMCI.OQ -25.1% PDD Holdings Inc PDD.OQ -6.3% Arm Holdings PLC ARM.OQ -5.5% Lululemon Athletica Inc LULU.OQ -4.4% Micron Technology Inc MU.OQ -4.3%
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Financial Times - Aug 8

PRESS DIGEST- Financial Times - Aug 8 Aug 8 (Reuters) - The following are the top stories in the Financial Times. Reuters has not verified these stories and does not vouch for their accuracy. Headlines - NHS in England to roll out 1.7 mln pound Crispr gene editing drug - Ministry of Defence asks suppliers to identify budget cuts - H2O Asset Management to pay investors 250 mln euros after FCA finds 'serious breaches' - UK signals move to curb overseas hiring for tech and engineering jobs Overview
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British Business - August 8

PRESS DIGEST-British Business - August 8 Aug 8 (Reuters) - The following are the top stories on the business pages of British newspapers. Reuters has not verified these stories and does not vouch for their accuracy. The Times - Asset manager H2O has agreed to pay out 250 million euros ($273.35 million) to investors who have been trapped since 2020 in illiquid funds linked to Lars Windhorst, the German financier.
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UK's NHS to roll out Vertex/CRISPR gene therapy for rare blood disorder

UPDATE 1-UK's NHS to roll out Vertex/CRISPR gene therapy for rare blood disorder Updates with details from statement in paragraphs 2-6, updates with background in paragraphs 7-8 Aug 7 (Reuters) - Britain's National Health Service (NHS) will begin to roll out a gene therapy from Vertex Pharmaceuticals VRTX.O and CRISPR Therapeutics CRSP.BN to treat rare blood disorder beta thalassemia, Vertex said in a statement on Wednesday.
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UK's NHS to roll out Vertex/CRISPR gene therapy for rare blood disorder

UPDATE 1-UK's NHS to roll out Vertex/CRISPR gene therapy for rare blood disorder Updates with details from statement in paragraphs 2-6, updates with background in paragraphs 7-8 Aug 7 (Reuters) - Britain's National Health Service (NHS) will begin to roll out a gene therapy from Vertex Pharmaceuticals VRTX.O and CRISPR Therapeutics CRSP.BN to treat rare blood disorder beta thalassemia, Vertex said in a statement on Wednesday.
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UK's NHS to roll out Vertex/CRISPR gene therapy for rare blood disorder

UK's NHS to roll out Vertex/CRISPR gene therapy for rare blood disorder Aug 7 (Reuters) - Britain's National Health Service(NHS) will begin rolling out Vertex Pharmaceuticals VRTX.O and CRISPR Therapeutics' CRSP.BN gene therapy to treat rare blood disorder beta thalassemia, Vertex said in a statement on Wednesday. Reporting by Gursimran Kaur in Ben
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Vertex Announces Casgevy Reimbursement Agreement For Treatment Of Transfusion-Dependent Beta Thalassemia In England

BRIEF-Vertex Announces Casgevy Reimbursement Agreement For Treatment Of Transfusion-Dependent Beta Thalassemia In England Aug 7 (Reuters) - Vertex Pharmaceuticals Inc VRTX.O : VERTEX ANNOUNCES CASGEVY™ REIMBURSEMENT AGREEMENT FOR THE TREATMENT OF TRANSFUSION-DEPENDENT BETA THALASSEMIA IN ENGLAND VERTEX PHARMACEUTICALS - ELIGIBLE TRANSFUSION-DEPEN
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US FDA approves Novartis' kidney disease drug

UPDATE 2-US FDA approves Novartis' kidney disease drug Adds background in paragraphs 6 to 10 By Sriparna Roy Aug 7 (Reuters) - The U.S. Food and Drug Administration has approved the use of Novartis' NOVN.S drug to reduce excess protein in the urine of patients with a type of kidney disease, the health regulator's website showed on Wednesday. The drug, Fabhalta, is already approved to treat adults with paroxysmal nocturnal hemoglobinuria, a rare blood disorder.
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U.S. Booking Holdings, Doordash, Vertex Pharmaceuticals

U.S. RESEARCH ROUNDUP- Booking Holdings, Doordash, Vertex Pharmaceuticals Aug 5 (Reuters) - Wall Street securities analysts revised their ratings and price targets on several U.S.-listed companies including Booking Holdings, Doordash and Vertex Pharmaceuticals, on Monday. HIGHLIGHTS * Academy Sports and Outdoors Inc ASO.O : JP Morgan cuts to neutral from overweight * Booking Holdings Inc BKNG.O : Jefferies cuts target price to $4350 from $4650 * Doordash DASH.O : D.A.
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